Demonstration of ganglioside GD3 in human reactive astrocytes
نویسندگان
چکیده
منابع مشابه
Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside.
GD3 ganglioside is an attractive target for immunotherapy of melanoma because it is abundantly expressed on all melanomas but not expressed on most normal tissues. Although GD3 has proven to be one of the least immunogenic gangliosides, our recent studies showed that anti-GD3 antibodies can be induced in patients immunized either with GD3-lactone-KLH (GD3-L-KLH) plus QS-21 adjuvant or with BEC2...
متن کاملExpression of GD3 Ganglioside in Childhood T-Cell Lymphoblastic Malignancies1
Lymphoblasts from seven children with T-cell lymphoblastic malig nancies and three children with non-T, non-B acute lymphoblastic leu kemia (ALL) were analyzed for ganglioside content. Nonmalignant I cells from thymus served as controls. Both ganglioside and glycoprotein sialic acid were increased approximately 3-3.5-fold in T-cell disease compared to thymic tissue when expressed on a per cell ...
متن کاملExpression of GD3 ganglioside in childhood T-cell lymphoblastic malignancies.
Lymphoblasts from seven children with T-cell lymphoblastic malignancies and three children with non-T, non-B acute lymphoblastic leukemia (ALL) were analyzed for ganglioside content. Nonmalignant T-cells from thymus served as controls. Both ganglioside and glycoprotein sialic acid were increased approximately 3-3.5-fold in T-cell disease compared to thymic tissue when expressed on a per cell ba...
متن کاملAcetylation Suppresses the Proapoptotic Activity of GD3 Ganglioside
GD3 synthase is rapidly activated in different cell types after specific apoptotic stimuli. De novo synthesized GD3 accumulates and contributes to the apoptotic program by relocating to mitochondrial membranes and inducing the release of apoptogenic factors. We found that sialic acid acetylation suppresses the proapoptotic activity of GD3. In fact, unlike GD3, 9-O-acetyl-GD3 is completely ineff...
متن کاملImmunohistochemical localization of ganglioside GD3 in human malignant melanoma, epithelial tumors, and normal tissues.
The specific tissue distribution of melanoma-associated ganglioside II3-alpha-N-acetylneuraminosyl-alpha 2----8-N-acetylneuraminosyllactosylceramide (GD3) was studied on 175 cryopreserved, unfixed human tissue sections with R-24 mouse monoclonal antibody by indirect immunoperoxidase staining. A striking specificity of monoclonal antibody R-24 for malignant melanoma tissues was established. Gang...
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ژورنال
عنوان ژورنال: Psychiatry and Clinical Neurosciences
سال: 1999
ISSN: 1323-1316,1440-1819
DOI: 10.1046/j.1440-1819.1999.00475.x